The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia

INTRODUCTION: The tyrosine phosphatase SHP-1 negatively influences endothelial function, such as VEGF signaling and reactive oxygen species (ROS) formation, and has been shown to influence angiogenesis during tissue ischemia. In ischemic tissues, hypoxia induced angiogenesis is crucial for restoring...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Alig, Stefan K., Stampnik, Yvonn, Pircher, Joachim, Rotter, Raffaela, Gaitzsch, Erik, Ribeiro, Andrea, Wörnle, Markus, Krötz, Florian, Mannell, Hanna
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370726/
https://ncbi.nlm.nih.gov/pubmed/25799543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121113
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