The Phosphatase SHP-2 Activates HIF-1α in Wounds In Vivo by Inhibition of 26S Proteasome Activity

Vascular remodeling and angiogenesis are required to improve the perfusion of ischemic tissues. The hypoxic environment, induced by ischemia, is a potent stimulus for hypoxia inducible factor 1α (HIF-1α) upregulation and activation, which induce pro-angiogenic gene expression. We previously showed t...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Heun, Yvonn, Grundler Groterhorst, Katharina, Pogoda, Kristin, Kraemer, Bjoern F, Pfeifer, Alexander, Pohl, Ulrich, Mannell, Hanna
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
Assuntos:
Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769879/
https://ncbi.nlm.nih.gov/pubmed/31500245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184404
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