HIF-1α Dependent Wound Healing Angiogenesis In Vivo Can Be Controlled by Site-Specific Lentiviral Magnetic Targeting of SHP-2

Hypoxia promotes vascularization by stabilization and activation of the hypoxia inducible factor 1α (HIF-1α), which constitutes a target for angiogenic gene therapy. However, gene therapy is hampered by low gene delivery efficiency and non-specific side effects. Here, we developed a gene transfer te...

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Vydáno v:Mol Ther
Hlavní autoři: Heun, Yvonn, Pogoda, Kristin, Anton, Martina, Pircher, Joachim, Pfeifer, Alexander, Woernle, Markus, Ribeiro, Andrea, Kameritsch, Petra, Mykhaylyk, Olga, Plank, Christian, Kroetz, Florian, Pohl, Ulrich, Mannell, Hanna
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498815/
https://ncbi.nlm.nih.gov/pubmed/28434868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.04.007
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