The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia

INTRODUCTION: The tyrosine phosphatase SHP-1 negatively influences endothelial function, such as VEGF signaling and reactive oxygen species (ROS) formation, and has been shown to influence angiogenesis during tissue ischemia. In ischemic tissues, hypoxia induced angiogenesis is crucial for restoring...

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Veröffentlicht in:PLoS One
Hauptverfasser: Alig, Stefan K., Stampnik, Yvonn, Pircher, Joachim, Rotter, Raffaela, Gaitzsch, Erik, Ribeiro, Andrea, Wörnle, Markus, Krötz, Florian, Mannell, Hanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370726/
https://ncbi.nlm.nih.gov/pubmed/25799543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121113
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