Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2

INTRODUCTION: Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα is known to induce prothrombotic molecules in endothelial cells. Based on the preexisting evidence for the impact of TNFα in th...

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Main Authors: Pircher, Joachim, Merkle, Monika, Wörnle, Markus, Ribeiro, Andrea, Czermak, Thomas, Stampnik, Yvonn, Mannell, Hanna, Niemeyer, Markus, Vielhauer, Volker, Krötz, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580536/
https://ncbi.nlm.nih.gov/pubmed/23079185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4064
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