Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2

INTRODUCTION: Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα is known to induce prothrombotic molecules in endothelial cells. Based on the preexisting evidence for the impact of TNFα in th...

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Main Authors: Pircher, Joachim, Merkle, Monika, Wörnle, Markus, Ribeiro, Andrea, Czermak, Thomas, Stampnik, Yvonn, Mannell, Hanna, Niemeyer, Markus, Vielhauer, Volker, Krötz, Florian
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580536/
https://ncbi.nlm.nih.gov/pubmed/23079185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4064
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