Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway

Programmed −1 ribosomal frameshift (−1 PRF) signals redirect translating ribosomes to slip back one base on messenger RNAs. Although well characterized in viruses, how these elements may regulate cellular gene expression is not understood. Here we describe a −1 PRF signal in the human mRNA encoding...

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Bibliografiset tiedot
Julkaisussa:Nature
Päätekijät: Belew, Ashton Trey, Meskauskas, Arturas, Musalgaonkar, Sharmishtha, Advani, Vivek M., Sulima, Sergey O., Kasprzak, Wojciech K., Shapiro, Bruce A., Dinman, Jonathan D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369343/
https://ncbi.nlm.nih.gov/pubmed/25043019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13429
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