Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence

Scl/Tal1 confers hemogenic competence and prevents ectopic cardiomyogenesis in embryonic endothelium by unknown mechanisms. We discovered that Scl binds to hematopoietic and cardiac enhancers that become epigenetically primed in multipotent cardiovascular mesoderm, to regulate the divergence of hema...

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Vydáno v:EMBO J
Hlavní autoři: Org, Tõnis, Duan, Dan, Ferrari, Roberto, Montel-Hagen, Amelie, Van Handel, Ben, Kerényi, Marc A, Sasidharan, Rajkumar, Rubbi, Liudmilla, Fujiwara, Yuko, Pellegrini, Matteo, Orkin, Stuart H, Kurdistani, Siavash K, Mikkola, Hanna KA
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369313/
https://ncbi.nlm.nih.gov/pubmed/25564442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490542
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