Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence

Scl/Tal1 confers hemogenic competence and prevents ectopic cardiomyogenesis in embryonic endothelium by unknown mechanisms. We discovered that Scl binds to hematopoietic and cardiac enhancers that become epigenetically primed in multipotent cardiovascular mesoderm, to regulate the divergence of hema...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Org, Tõnis, Duan, Dan, Ferrari, Roberto, Montel-Hagen, Amelie, Van Handel, Ben, Kerényi, Marc A, Sasidharan, Rajkumar, Rubbi, Liudmilla, Fujiwara, Yuko, Pellegrini, Matteo, Orkin, Stuart H, Kurdistani, Siavash K, Mikkola, Hanna KA
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2015
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369313/
https://ncbi.nlm.nih.gov/pubmed/25564442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490542
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