Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence

Scl/Tal1 confers hemogenic competence and prevents ectopic cardiomyogenesis in embryonic endothelium by unknown mechanisms. We discovered that Scl binds to hematopoietic and cardiac enhancers that become epigenetically primed in multipotent cardiovascular mesoderm, to regulate the divergence of hema...

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Bibliografski detalji
Izdano u:EMBO J
Glavni autori: Org, Tõnis, Duan, Dan, Ferrari, Roberto, Montel-Hagen, Amelie, Van Handel, Ben, Kerényi, Marc A, Sasidharan, Rajkumar, Rubbi, Liudmilla, Fujiwara, Yuko, Pellegrini, Matteo, Orkin, Stuart H, Kurdistani, Siavash K, Mikkola, Hanna KA
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369313/
https://ncbi.nlm.nih.gov/pubmed/25564442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490542
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