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Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence
Scl/Tal1 confers hemogenic competence and prevents ectopic cardiomyogenesis in embryonic endothelium by unknown mechanisms. We discovered that Scl binds to hematopoietic and cardiac enhancers that become epigenetically primed in multipotent cardiovascular mesoderm, to regulate the divergence of hema...
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| Veröffentlicht in: | EMBO J |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BlackWell Publishing Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4369313/ https://ncbi.nlm.nih.gov/pubmed/25564442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490542 |
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