Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence

Scl/Tal1 confers hemogenic competence and prevents ectopic cardiomyogenesis in embryonic endothelium by unknown mechanisms. We discovered that Scl binds to hematopoietic and cardiac enhancers that become epigenetically primed in multipotent cardiovascular mesoderm, to regulate the divergence of hema...

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Publicado en:EMBO J
Autores principales: Org, Tõnis, Duan, Dan, Ferrari, Roberto, Montel-Hagen, Amelie, Van Handel, Ben, Kerényi, Marc A, Sasidharan, Rajkumar, Rubbi, Liudmilla, Fujiwara, Yuko, Pellegrini, Matteo, Orkin, Stuart H, Kurdistani, Siavash K, Mikkola, Hanna KA
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2015
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369313/
https://ncbi.nlm.nih.gov/pubmed/25564442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490542
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