Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage

Affinity maturation, the process in which somatic hypermutation and positive selection generate antibodies with increasing affinity for an antigen, is pivotal in acquired humoral immunity. We have studied the mechanism of affinity gain in a human B-cell lineage in which two main maturation pathways,...

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Bibliografiska uppgifter
I publikationen:Proteins
Huvudupphovsmän: Xu, Huafeng, Schmidt, Aaron G, O'Donnell, Timothy, Therkelsen, Matthew D, Kepler, Thomas B, Moody, M Anthony, Haynes, Barton F, Liao, Hua-Xin, Harrison, Stephen C, Shaw, David E
Materialtyp: Artigo
Språk:Inglês
Publicerad: BlackWell Publishing Ltd 2015
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368477/
https://ncbi.nlm.nih.gov/pubmed/25524709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24745
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