Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies

Induction of HIV-1 broad neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development but has remained challenging partially due to unusual traits of bnAbs, including high somatic hypermutation (SHM) frequencies and in-frame insertions and deletions (indels). Here we examined the propensit...

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Main Authors: Kepler, Thomas B., Liao, Hua-Xin, Alam, S. Munir, Bhaskarabhatla, Rekha, Zhang, Ruijun, Stewart, Shelley, Anasti, Kara, Kelsoe, Garnett, Parks, Robert, Lloyd, Krissey E., Stolarchuk, Christina, Pritchett, Jamie, Solomon, Erika, Friberg, Emma, Morris, Lynn, Karim, Salim S. Abdool, Cohen, Myron S., Walter, Emmanuel, Moody, M. Anthony, Wu, Xueling, Altae-Tran, Han R., Georgiev, Ivelin S., Kwong, Peter D., Boyd, Scott D., Fire, Andrew Z., Mascola, John R., Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163498/
https://ncbi.nlm.nih.gov/pubmed/25211073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.08.006
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