Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

Affinity maturation refines a naive B-cell response by selecting mutations in antibody variable domains that enhance antigen binding. We describe a B-cell lineage expressing broadly neutralizing influenza virus antibodies derived from a subject immunized with the 2007 trivalent vaccine. The lineage...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Schmidt, Aaron G., Xu, Huafeng, Khan, Amir R., O’Donnell, Timothy, Khurana, Surender, King, Lisa R., Manischewitz, Jody, Golding, Hana, Suphaphiphat, Pirada, Carfi, Andrea, Settembre, Ethan C., Dormitzer, Philip R., Kepler, Thomas B., Zhang, Ruijun, Moody, M. Anthony, Haynes, Barton F., Liao, Hua-Xin, Shaw, David E., Harrison, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538208/
https://ncbi.nlm.nih.gov/pubmed/23175789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218256109
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados