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Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains
Rapidly evolving pathogens, such as human immunodeficiency and influenza viruses, escape immune defenses provided by most vaccine-induced antibodies. Proposed strategies to elicit broadly neutralizing antibodies require a deeper understanding of antibody affinity maturation and evolution of the immu...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104889/ https://ncbi.nlm.nih.gov/pubmed/24982157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409954111 |
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