Interleukin-7 co-ordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

pre-T cell receptor (TCR) and Notch signaling induce transient self-renewal or “β-selection” of TCRβ(+) CD4 CD8 double-negative-3 (DN3) and DN4 progenitors that differentiate into CD4 CD8 double positive (DP) thymocytes which then rearrange Tcra. Interleukin-7 (IL-7) promotes Bcl2-dependent survival...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Boudil, Amine, Matei, Irina R., Shih, Han-Yu, Bogdanoski, Goce, Yuan, Julie S., Chang, Stephen G., Montpellier, Bertrand, Kowalski, Paul E., Voisin, Veronique, Bashir, Shaheena, Bader, Gary D., Krangel, Michael S., Guidos, Cynthia J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368453/
https://ncbi.nlm.nih.gov/pubmed/25729925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3122
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