Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub

Antigen receptor locus V(D)J recombination requires interactions between widely separated variable (V), diversity (D), and joining (J) gene segments, but the mechanisms that generate these interactions are not well understood. Here we assessed mechanisms that direct developmental stage-specific long...

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Bibliografiska uppgifter
Huvudupphovsmän: Shih, Han-Yu, Verma-Gaur, Jiyoti, Torkamani, Ali, Feeney, Ann J., Galjart, Niels, Krangel, Michael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528579/
https://ncbi.nlm.nih.gov/pubmed/23169622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214131109
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