A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation

Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the different species. For discovery of a diverse panel of unique therapeutic antibody candidates, chickens therefore represent an attractive host for human-derived...

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Publicat a:Front Immunol
Autors principals: Leighton, Philip A., Schusser, Benjamin, Yi, Henry, Glanville, Jacob, Harriman, William
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367436/
https://ncbi.nlm.nih.gov/pubmed/25852694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00126
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