A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation

Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the different species. For discovery of a diverse panel of unique therapeutic antibody candidates, chickens therefore represent an attractive host for human-derived...

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Pubblicato in:Front Immunol
Autori principali: Leighton, Philip A., Schusser, Benjamin, Yi, Henry, Glanville, Jacob, Harriman, William
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367436/
https://ncbi.nlm.nih.gov/pubmed/25852694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00126
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