Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil. Variable (V) region genes undergo SHM to create amino acid substitutions that produce antibodies...

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Detaylı Bibliyografya
Yayımlandı:Front Immunol
Asıl Yazarlar: Costello, Ryan, Cantillo, Jose F., Kenter, Amy L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2019
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838969/
https://ncbi.nlm.nih.gov/pubmed/31736964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02540
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