Familial Parkinson Disease-associated Mutations Alter the Site-specific Microenvironment and Dynamics of α-Synuclein

Human α-synuclein (α-Syn) is a natively unstructured protein whose aggregation into amyloid fibrils is associated with Parkinson disease (PD) pathogenesis. Mutations of α-Syn, E46K, A53T, and A30P, have been linked to the familial form of PD. In vitro aggregation studies suggest that increased prope...

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Udgivet i:J Biol Chem
Main Authors: Sahay, Shruti, Ghosh, Dhiman, Dwivedi, Saumya, Anoop, Arunagiri, Mohite, Ganesh Maruti, Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Maji, Samir K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367280/
https://ncbi.nlm.nih.gov/pubmed/25635052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.598607
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