Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils

Parkinson's disease is mainly a sporadic disorder in which both environmental and cellular factors play a major role in the initiation of this disease. Glycosaminoglycans (GAG) are integral components of the extracellular matrix and are known to influence amyloid aggregation of several proteins...

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Pubblicato in:J Biol Chem
Autori principali: Mehra, Surabhi, Ghosh, Dhiman, Kumar, Rakesh, Mondal, Mrityunjoy, Gadhe, Laxmikant G., Das, Subhadeep, Anoop, Arunagiri, Jha, Narendra N., Jacob, Reeba S., Chatterjee, Debdeep, Ray, Soumik, Singh, Nitu, Kumar, Ashutosh, Maji, Samir K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109935/
https://ncbi.nlm.nih.gov/pubmed/29959225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004267
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