Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity

Alpha-synuclein (α-Syn) aggregation into oligomers and fibrils is associated with dopaminergic neuron loss occurring in Parkinson’s disease (PD) pathogenesis. Compounds that modulate α-Syn aggregation and interact with preformed fibrils/oligomers and convert them to less toxic species could have pro...

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Publicat a:Sci Rep
Autors principals: Jha, Narendra Nath, Ghosh, Dhiman, Das, Subhadeep, Anoop, Arunagiri, Jacob, Reeba S., Singh, Pradeep K., Ayyagari, Narasimham, Namboothiri, Irishi N. N., Maji, Samir K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919791/
https://ncbi.nlm.nih.gov/pubmed/27338805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28511
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