p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis

The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of human cancers are associated with the loss of p53 functions, where p53 often accumulates in the nucleus as well as in cytoplasm. Although it has been previously suggested that amyloid formation could be a cau...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Main Authors: Ghosh, Saikat, Salot, Shimul, Sengupta, Shinjinee, Navalkar, Ambuja, Ghosh, Dhiman, Jacob, Reeba, Das, Subhadeep, Kumar, Rakesh, Jha, Narendra Nath, Sahay, Shruti, Mehra, Surabhi, Mohite, Ganesh M, Ghosh, Santanu K, Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Chaudhari, Pradip, Maji, Samir K
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
Assuntos:
Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596421/
https://ncbi.nlm.nih.gov/pubmed/28644435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.105
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