p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis

The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of human cancers are associated with the loss of p53 functions, where p53 often accumulates in the nucleus as well as in cytoplasm. Although it has been previously suggested that amyloid formation could be a cau...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Ghosh, Saikat, Salot, Shimul, Sengupta, Shinjinee, Navalkar, Ambuja, Ghosh, Dhiman, Jacob, Reeba, Das, Subhadeep, Kumar, Rakesh, Jha, Narendra Nath, Sahay, Shruti, Mehra, Surabhi, Mohite, Ganesh M, Ghosh, Santanu K, Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Chaudhari, Pradip, Maji, Samir K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596421/
https://ncbi.nlm.nih.gov/pubmed/28644435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.105
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