Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter

[Image: see text] The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. To expand CHT pharmacology, we pursued a hig...

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Publicat a:ACS Chem Neurosci
Autors principals: Ennis, Elizabeth A., Wright, Jane, Retzlaff, Cassandra L., McManus, Owen B., Lin, Zhinong, Huang, Xiaofang, Wu, Meng, Li, Min, Daniels, J. Scott, Lindsley, Craig W., Hopkins, Corey R., Blakely, Randy D.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367188/
https://ncbi.nlm.nih.gov/pubmed/25560927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn5001809
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