Nonoisotopic Assay for the Presynaptic Choline Transporter Reveals Capacity for Allosteric Modulation of Choline Uptake

[Image: see text] Current therapies to enhance CNS cholinergic function rely primarily on extracellular acetylcholinesterase (AChE) inhibition, a pharmacotherapeutic strategy that produces dose-limiting side effects. The Na(+)-dependent, high-affinity choline transporter (CHT) is an unexplored targe...

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Autors principals: Ruggiero, Alicia M., Wright, Jane, Ferguson, Shawn M., Lewis, Michelle, Emerson, Katie S., Iwamoto, Hideki, Ivy, Michael T., Holmstrand, Ericka C., Ennis, Elizabeth. A., Weaver, C. David, Blakely, Randy D.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474274/
https://ncbi.nlm.nih.gov/pubmed/23077721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3000718
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