MAPK Phosphatase 7 Regulates T Cell Differentiation via Inhibiting ERK-Mediated IL-2 Expression

Members of the MAPK phosphatase (MKP) protein family play critical roles in immune responses through differential regulation of MAPK activation. In this study, we show that MKP7, also known as dual-specificity phosphatase 16, was required for CD4(+) T cell responses in vivo. Mkp7(−/−) CD4(+) T cells...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Zhang, Yongliang, Nallaparaju, Kalyan C., Liu, Xin, Jiao, Huipeng, Reynolds, Joseph M., Wang, Zhi-Xin, Dong, Chen
Format: Artigo
Jezik:Inglês
Izdano: AAI 2015
Teme:
Immune Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367158/
https://ncbi.nlm.nih.gov/pubmed/25716993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402638
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