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MAPK Phosphatase 7 Regulates T Cell Differentiation via Inhibiting ERK-Mediated IL-2 Expression

Members of the MAPK phosphatase (MKP) protein family play critical roles in immune responses through differential regulation of MAPK activation. In this study, we show that MKP7, also known as dual-specificity phosphatase 16, was required for CD4(+) T cell responses in vivo. Mkp7(−/−) CD4(+) T cells...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Zhang, Yongliang, Nallaparaju, Kalyan C., Liu, Xin, Jiao, Huipeng, Reynolds, Joseph M., Wang, Zhi-Xin, Dong, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367158/
https://ncbi.nlm.nih.gov/pubmed/25716993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402638
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