Inhibiting Protein Arginine Deiminases Has Antioxidant Consequences

Ulcerative colitis is a dynamic, idiopathic, chronic inflammatory condition that carries a high colon cancer risk. We previously showed that Cl-amidine, a small-molecule inhibitor of the protein arginine deiminases, suppresses colitis in mice. Because colitis is defined as inflammation of the colon...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Witalison, Erin E., Cui, Xiangli, Hofseth, Anne B., Subramanian, Venkataraman, Causey, Corey P., Thompson, Paul R., Hofseth, Lorne J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2015
Schlagworte:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366755/
https://ncbi.nlm.nih.gov/pubmed/25635139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.222745
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