d-Amino Acid-Based Protein Arginine Deiminase Inhibitors: Synthesis, Pharmacokinetics, and in Cellulo Efficacy

[Image: see text] The protein arginine deiminases (PADs) are known to play a crucial role in the onset and progression of multiple inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. However, it is not known how each of the five PAD isozymes contributes to...

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Detalhes bibliográficos
Main Authors: Bicker, Kevin L., Anguish, Lynne, Chumanevich, Alexander A., Cameron, Michael D., Cui, Xiangli, Witalison, Erin, Subramanian, Venkataraman, Zhang, Xuesen, Chumanevich, Alena P., Hofseth, Lorne J., Coonrod, Scott A., Thompson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572853/
https://ncbi.nlm.nih.gov/pubmed/23420624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300288d
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