d-Amino Acid-Based Protein Arginine Deiminase Inhibitors: Synthesis, Pharmacokinetics, and in Cellulo Efficacy

[Image: see text] The protein arginine deiminases (PADs) are known to play a crucial role in the onset and progression of multiple inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. However, it is not known how each of the five PAD isozymes contributes to...

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Bibliographic Details
Main Authors: Bicker, Kevin L., Anguish, Lynne, Chumanevich, Alexander A., Cameron, Michael D., Cui, Xiangli, Witalison, Erin, Subramanian, Venkataraman, Zhang, Xuesen, Chumanevich, Alena P., Hofseth, Lorne J., Coonrod, Scott A., Thompson, Paul R.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572853/
https://ncbi.nlm.nih.gov/pubmed/23420624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300288d
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