Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase Inhibitors

[Image: see text] Protein arginine deiminases (PADs) catalyze the post-translational hydrolysis of arginine residues to form citrulline. This once obscure modification is now known to play a key role in the etiology of multiple autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis, lup...

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Publicado en:J Med Chem
Autores principales: Subramanian, Venkataraman, Knight, Jason S., Parelkar, Sangram, Anguish, Lynne, Coonrod, Scott A., Kaplan, Mariana J., Thompson, Paul R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2015
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4610306/
https://ncbi.nlm.nih.gov/pubmed/25559347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501636x
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