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Spec-seq: determining protein–DNA-binding specificity by sequencing
The specificity of protein–DNA interactions can be determined directly by sequencing the bound and unbound fractions in a standard binding reaction. The procedure is easy and inexpensive, and the accuracy can be high for thousands of sequences assayed in parallel. From the measurements, simple model...
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| izdano v: | Brief Funct Genomics |
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| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366588/ https://ncbi.nlm.nih.gov/pubmed/25362070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bfgp/elu043 |
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