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Inherent limitations of probabilistic models for protein-DNA binding specificity

The specificities of transcription factors are most commonly represented with probabilistic models. These models provide a probability for each base occurring at each position within the binding site and the positions are assumed to contribute independently. The model is simple and intuitive and is...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Ruan, Shuxiang, Stormo, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5521849/
https://ncbi.nlm.nih.gov/pubmed/28686588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005638
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