Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

The brains of Alzheimer’s disease (AD) patients are characterized by deposits of Abeta peptides and by accompanying chronic inflammation. Here, we provide evidence that the enzyme isoglutaminyl cyclase (isoQC) is a novel factor contributing to both aspects of AD pathology. Two putative substrates of...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Hartlage-Rübsamen, Maike, Waniek, Alexander, Meißner, Juliane, Morawski, Markus, Schilling, Stephan, Jäger, Carsten, Kleinschmidt, Martin, Cynis, Holger, Kehlen, Astrid, Arendt, Thomas, Demuth, Hans-Ulrich, Roßner, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366547/
https://ncbi.nlm.nih.gov/pubmed/25666182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1395-2
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