Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

The brains of Alzheimer’s disease (AD) patients are characterized by deposits of Abeta peptides and by accompanying chronic inflammation. Here, we provide evidence that the enzyme isoglutaminyl cyclase (isoQC) is a novel factor contributing to both aspects of AD pathology. Two putative substrates of...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol
Main Authors: Hartlage-Rübsamen, Maike, Waniek, Alexander, Meißner, Juliane, Morawski, Markus, Schilling, Stephan, Jäger, Carsten, Kleinschmidt, Martin, Cynis, Holger, Kehlen, Astrid, Arendt, Thomas, Demuth, Hans-Ulrich, Roßner, Steffen
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2015
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366547/
https://ncbi.nlm.nih.gov/pubmed/25666182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1395-2
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