Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease

Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally truncated Alzheimer’s disease (AD) Aβ peptides in vivo. This modification confers resistance to proteolysis, rapid aggregation and neurotoxicity and can be prevented b...

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Detalhes bibliográficos
Main Authors: Morawski, Markus, Hartlage-Rübsamen, Maike, Jäger, Carsten, Waniek, Alexander, Schilling, Stephan, Schwab, Claudia, McGeer, Patrick L., Arendt, Thomas, Demuth, Hans-Ulrich, Roßner, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892616/
https://ncbi.nlm.nih.gov/pubmed/20383514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-010-0685-y
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