Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation

Oligomeric assemblies of neurotoxic amyloid beta (Abeta) peptides generated by proteolytical processing of the amyloid precursor protein (APP) play a key role in the pathogenesis of Alzheimer’s disease (AD). In recent years, a substantial heterogeneity of Abeta peptides with distinct biophysical and...

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Pubblicato in:Molecules
Autori principali: Hartlage-Rübsamen, Maike, Bluhm, Alexandra, Piechotta, Anke, Linnert, Miriam, Rahfeld, Jens-Ulrich, Demuth, Hans-Ulrich, Lues, Inge, Kuhn, Peer-Hendrik, Lichtenthaler, Stefan F., Roßner, Steffen, Höfling, Corinna
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017857/
https://ncbi.nlm.nih.gov/pubmed/29673150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23040924
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