Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease

Pathogenic variants of the huntingtin (HTT) protein and their aggregation have been investigated in great detail in brains of Huntington’s disease patients and HTT-transgenic animals. However, little is known about the physiological brain region- and cell type-specific HTT expression pattern in wild...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Hartlage-Rübsamen, Maike, Ratz, Veronika, Zeitschel, Ulrike, Finzel, Lukas, Machner, Lisa, Köppen, Janett, Schulze, Anja, Demuth, Hans-Ulrich, von Hörsten, Stephan, Höfling, Corinna, Roßner, Steffen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526682/
https://ncbi.nlm.nih.gov/pubmed/31109380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0726-2
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