shRNA Off-Target Effects In Vivo: Impaired Endogenous siRNA Expression and Spermatogenic Defects

RNA interference (RNAi) is widely used to determine the function of genes. We chose this approach to assess the collective function of the highly related reproductive homeobox 3 (Rhox3) gene paralogs. Using a Rhox3 short hairpin (sh) RNA with 100% complementarity to all 8 Rhox3 paralogs, expressed f...

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Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Song, Hye-Won, Bettegowda, Anilkumar, Oliver, Daniel, Yan, Wei, Phan, Mimi H., de Rooij, Dirk G., Corbett, Mark A., Wilkinson, Miles F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366048/
https://ncbi.nlm.nih.gov/pubmed/25790000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118549
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