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A Genome-Wide siRNA Screen in Mammalian Cells for Regulators of S6 Phosphorylation
mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activated in most cancers. We performed a genome-wide RNAi screen in a human cancer cell line, seeking genes that regulate S6 phosphorylation, readout of mTORC1 activity. Applying a stringent selection, we re...
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| Yayımlandı: | PLoS One |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366019/ https://ncbi.nlm.nih.gov/pubmed/25790369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116096 |
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