Genome-wide siRNA screen for mediators of NF-κB activation

Although canonical NFκB is frequently critical for cell proliferation, survival, or differentiation, NFκB hyperactivation can cause malignant, inflammatory, or autoimmune disorders. Despite intensive study, mammalian NFκB pathway loss-of-function RNAi analyses have been limited to specific protein c...

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Detalhes bibliográficos
Main Authors: Gewurz, Benjamin E., Towfic, Fadi, Mar, Jessica C., Shinners, Nicholas P., Takasaki, Kaoru, Zhao, Bo, Cahir-McFarland, Ellen D., Quackenbush, John, Xavier, Ramnik J., Kieff, Elliott
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289371/
https://ncbi.nlm.nih.gov/pubmed/22308454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120542109
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