A Genome-Wide siRNA Screen in Mammalian Cells for Regulators of S6 Phosphorylation

mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activated in most cancers. We performed a genome-wide RNAi screen in a human cancer cell line, seeking genes that regulate S6 phosphorylation, readout of mTORC1 activity. Applying a stringent selection, we re...

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Bibliographic Details
Published in:PLoS One
Main Authors: Papageorgiou, Angela, Rapley, Joseph, Mesirov, Jill P., Tamayo, Pablo, Avruch, Joseph
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366019/
https://ncbi.nlm.nih.gov/pubmed/25790369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116096
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