Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

The cellular prion protein (PrP(C)) comprises a natively unstructured N-terminal domain, including a metal-binding octarepeat region (OR) and a linker, followed by a C-terminal domain that misfolds to form PrP(S)(c) in Creutzfeldt-Jakob disease. PrP(C) β-endoproteolysis to the C2 fragment allows PrP...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Lau, Agnes, McDonald, Alex, Daude, Nathalie, Mays, Charles E, Walter, Eric D, Aglietti, Robin, Mercer, Robert CC, Wohlgemuth, Serene, van der Merwe, Jacques, Yang, Jing, Gapeshina, Hristina, Kim, Chae, Grams, Jennifer, Shi, Beipei, Wille, Holger, Balachandran, Aru, Schmitt-Ulms, Gerold, Safar, Jiri G, Millhauser, Glenn L, Westaway, David
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364950/
https://ncbi.nlm.nih.gov/pubmed/25661904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404588
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