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A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design
Antibody drug conjugates (ADCs) represent novel anti-cancer modalities engineered to specifically target and kill tumor cells expressing corresponding antigens. Due to their large size and their complex kinetics, these therapeutic agents often face heterogeneous distributions in tumors, leading to l...
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| I publikationen: | PLoS One |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4364906/ https://ncbi.nlm.nih.gov/pubmed/25786126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118977 |
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