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A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design

Antibody drug conjugates (ADCs) represent novel anti-cancer modalities engineered to specifically target and kill tumor cells expressing corresponding antigens. Due to their large size and their complex kinetics, these therapeutic agents often face heterogeneous distributions in tumors, leading to l...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Vasalou, Christina, Helmlinger, Gabriel, Gomes, Bruce
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364906/
https://ncbi.nlm.nih.gov/pubmed/25786126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118977
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