Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

PURPOSE: A semi-mechanistic multiple-analyte population pharmacokinetics (PK) model was developed to describe the complex relationship between the different analytes of monomethyl auristatin E (MMAE) containing antibody-drug conjugates (ADCs) and to provide insight regarding the major pathways of co...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Lu, Dan, Jin, Jin Yan, Girish, Sandhya, Agarwal, Priya, Li, Dongwei, Prabhu, Saileta, Dere, Randall C., Saad, Ola M., Nazzal, Denise, Koppada, Neelima, Ramanujan, Saroja, Ng, Chee M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422865/
https://ncbi.nlm.nih.gov/pubmed/25467958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1585-y
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