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Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology

Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have exhibited limited clinical efficacy, in part, due to insufficient penetration within tumors. To better understand the relationship between ADC tum...

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Bibliografiske detaljer
Udgivet i:Clin Transl Sci
Main Authors: Weddell, Jared, Chiney, Manoj S., Bhatnagar, Sumit, Gibbs, John P., Shebley, Mohamad
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877868/
https://ncbi.nlm.nih.gov/pubmed/33073529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12892
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