IMD-4690, a Novel Specific Inhibitor for Plasminogen Activator Inhibitor-1, Reduces Allergic Airway Remodeling in a Mouse Model of Chronic Asthma via Regulating Angiogenesis and Remodeling-Related Mediators

Plasminogen activator inhibitor (PAI)-1 is the principal inhibitor of plasminogen activators, and is responsible for the degradation of fibrin and extracellular matrix. IMD-4690 is a newly synthesized inhibitor for PAI-1, whereas the effect on allergic airway inflammation and remodeling is still unc...

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Veröffentlicht in:PLoS One
Hauptverfasser: Tezuka, Toshifumi, Ogawa, Hirohisa, Azuma, Masahiko, Goto, Hisatsugu, Uehara, Hisanori, Aono, Yoshinori, Hanibuchi, Masaki, Yamaguchi, Yoichi, Fujikawa, Tomoyuki, Itai, Akiko, Nishioka, Yasuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364779/
https://ncbi.nlm.nih.gov/pubmed/25785861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121615
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