Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice

Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of pulmonary fibrosis. Nintedanib, a multi-kinase inhibitor that targets several tyrosine kinases, including PDGF receptor (PDGFR), was recently approved as an anti-fibrotic agent to reduce the deterioration of FVC in pati...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kishi, Masami, Aono, Yoshinori, Sato, Seidai, Koyama, Kazuya, Azuma, Momoyo, Abe, Shuichi, Kawano, Hiroshi, Kishi, Jun, Toyoda, Yuko, Okazaki, Hiroyasu, Ogawa, Hirohisa, Uehara, Hisanori, Nishioka, Yasuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312310/
https://ncbi.nlm.nih.gov/pubmed/30596712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209786
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