Targeted reduction of CCR4(+) cells is sufficient to suppress allergic airway inflammation

BACK GROUND: Bronchial asthma is characterized by allergic airway inflammation involving C-C chemokine receptor type 4 (CCR4)-positive Th2 cells. As such, we hypothesize that the disease can be alleviated by targeted-elimination of CCR4(+) cells. Thymus and activation-regulated chemokine (TARC)-PE38...

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Detalhes bibliográficos
Publicado no:Respir Investig
Main Authors: Honjo, Akifumi, Ogawa, Hirohisa, Azuma, Masahiko, Tezuka, Toshifumi, Sone, Saburo, Biragyn, Arya, Nishioka, Yasuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846619/
https://ncbi.nlm.nih.gov/pubmed/24238232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resinv.2013.04.007
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