Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Antiretroviral therapy (ART) suppresses HIV replication in most individuals but cannot eradicate latently infected cells established before ART was initiated. Thus, infection rebounds when treatment is interrupted by reactivation of virus production from this reservoir. Currently, one or a few laten...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Rothenberger, Meghan K., Keele, Brandon F., Wietgrefe, Stephen W., Fletcher, Courtney V., Beilman, Gregory J., Chipman, Jeffrey G., Khoruts, Alexander, Estes, Jacob D., Anderson, Jodi, Callisto, Samuel P., Schmidt, Thomas E., Thorkelson, Ann, Reilly, Cavan, Perkey, Katherine, Reimann, Thomas G., Utay, Netanya S., Nganou Makamdop, Krystelle, Stevenson, Mario, Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364237/
https://ncbi.nlm.nih.gov/pubmed/25713386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414926112
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