Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Antiretroviral therapy (ART) suppresses HIV replication in most individuals but cannot eradicate latently infected cells established before ART was initiated. Thus, infection rebounds when treatment is interrupted by reactivation of virus production from this reservoir. Currently, one or a few laten...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Rothenberger, Meghan K., Keele, Brandon F., Wietgrefe, Stephen W., Fletcher, Courtney V., Beilman, Gregory J., Chipman, Jeffrey G., Khoruts, Alexander, Estes, Jacob D., Anderson, Jodi, Callisto, Samuel P., Schmidt, Thomas E., Thorkelson, Ann, Reilly, Cavan, Perkey, Katherine, Reimann, Thomas G., Utay, Netanya S., Nganou Makamdop, Krystelle, Stevenson, Mario, Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364237/
https://ncbi.nlm.nih.gov/pubmed/25713386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414926112
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